Anti-CD48(APC) Monoclonal Antibody, 100.0T

Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including 2B4/CD244 or CD2 to regulate immune cell function and activation (PubMed:27249817, PubMed:12007789).Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291).In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789).Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:9841922, PubMed:27249817).

• Size: 100.0T
• Physical State: Liquid
• Storage: Store at 4℃ in dark.Do not freeze.
• Application: FCM
• Brand: Saint Michael
• Catalogue No.: K010612M-100.0T

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.