Anti-CD49d(FITC) Monoclonal Antibody, 100.0T

Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.

• Size: 100.0T
• Physical State: Liquid
• Storage: Store at 4℃ in dark.Do not freeze.
• Application: FCM
• Brand: Saint Michael
• Catalogue No.: K010812M-100.0T

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.