Anti-HIF 2 alpha Polyclonal Antibody, 50.0ul
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
- Size: 50.0ul
- Molecular Weight: 96kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze / thaw cycles.
- Application: IHC;WB;ELISA;FCM;IF
- Brand: Saint Michael
- Catalogue No.: K009522P-50.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.