Anti-INSR Polyclonal Antibody, 50.0ul

The insulin receptor is a heterotetrameric membrane glycoprotein with tyrosine-protein kinase activity, consisting of disulfide-linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit possesses a single transmembrane domain, whereas the alpha subunit is completely extracellular. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Binding of insulin to the insulin receptor stimulates its association with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K) which leads to glucose uptake. Two transcript variants encoding different isoforms have been found for this gene produced by alternative splicing.

• Size: 50.0ul
• Molecular Weight: 156kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Application: ELISA;FCM;IF;IHC;WB
• Brand: Saint Michael
• Catalogue No.: K009708P-50.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.