• Sign In
  • Create an Account
Toggle Nav
My Cart
Search
Advanced Search
  • Compare Products
Menu
Account
main product photo

Anti-Lin28B Polyclonal Antibody, 100.0ul

Be the first to review this product
£529.66
Delivery: 2 weeks
SKU
K009663P-100.0ul
Add to Wish List Add to Compare
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif

Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

  • Size: 100.0ul
  • Molecular Weight: 27kDa
  • Physical State: Liquid
  • Storage: Store at -20℃. Avoid freeze / thaw cycles.
  • Application: ELISA;IF;IHC;WB
  • Brand: Saint Michael
  • Catalogue No.: K009663P-100.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.

Reviews
Write Your Own Review
You're reviewing:Anti-Lin28B Polyclonal Antibody, 100.0ul
© 2026 Excalibur Labware. All products are for laboratory research use only.