Anti-NR3C1 Polyclonal Antibody, 100.0ul

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.

• Size: 100.0ul
• Molecular Weight: 52/76/61/65/82/86kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze/thaw cycles.
• Application: WB
• Brand: Saint Michael
• Catalogue No.: K101529P-100.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.