Anti-OAZ1 Polyclonal Antibody, 20.0ul

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family; which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting; which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC); the key enzyme in polyamine biosynthesis; thus; completing the auto-regulatory circuit. This gene encodes antizyme 1; the first member of the antizyme family; that has broad tissue distribution; and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation; as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

• Size: 20.0ul
• Molecular Weight: 25kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Application: IHC
• Brand: Saint Michael
• Catalogue No.: K114807P-20.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.