Anti-PARP16 Polyclonal Antibody, 50.0ul

Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:22701565, PubMed:23103912, PubMed:25043379, PubMed:34314702).Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading (PubMed:34314702).Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 (PubMed:34314702).Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912).May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565).May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).

• Size: 50.0ul
• Molecular Weight: 23/36KDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Application: IHC;WB
• Brand: Saint Michael
• Catalogue No.: K116017P-50.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.