Anti-PDHA1 Polyclonal Antibody, 50.0ul
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Size: 50.0ul
- Molecular Weight: 40/43/44/47kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze/thaw cycles.
- Application: IHC;WB;IP;IF
- Brand: Saint Michael
- Catalogue No.: K003062P-50.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.