Anti-PDX1 Polyclonal Antibody, 100.0ul

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

• Size: 100.0ul
• Molecular Weight: 31Da
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze/thaw cycles.
• Application: IHC;WB;ELISA
• Brand: Saint Michael
• Catalogue No.: K106453P-100.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.