Anti-PGC1 alpha/beta Polyclonal Antibody, 100.0ul

PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

• Size: 100.0ul
• Molecular Weight: 91kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Application: WB
• Brand: Saint Michael
• Catalogue No.: K010150P-100.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.