Anti-POLE Polyclonal Antibody, 100.0ul
Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849).Participates in chromosomal DNA replication (By similarity).Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity).Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity).Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199).Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374).
- Size: 100.0ul
- Molecular Weight: 262kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze / thaw cycles.
- Application: WB
- Brand: Saint Michael
- Catalogue No.: K113101P-100.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.