Anti-PTCH1 Polyclonal Antibody, 50.0ul
This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly.
- Size: 50.0ul
- Molecular Weight: 161kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze / thaw cycles.
- Application: WB;IF
- Brand: Saint Michael
- Catalogue No.: K010514P-50.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.