Anti-RAD17 Polyclonal Antibody, 20.0ul

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

• Size: 20.0ul
• Molecular Weight: 57/66/75/77kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze/thaw cycles.
• Application: IHC
• Brand: Saint Michael
• Catalogue No.: K111070P-20.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.