Anti-SEPTIN2 Polyclonal Antibody, 100.0ul

Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12; SEPTIN6; SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules; thus facilitating efficient vesicle transport; and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase; may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia; required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens; Listeria monocytogenes and Shigella flexneri.

• Size: 100.0ul
• Molecular Weight: 41/43/45kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze/thaw cycles.
• Application: WB
• Brand: Saint Michael
• Catalogue No.: K108257P-100.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.