Anti-SMAD7 Polyclonal Antibody, 20.0ul
£72.56
Delivery: 2 weeks
SKU
K106646P-20.0ul
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociati
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- Size: 20.0ul
- Molecular Weight: 46kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze/thaw cycles.
- Application: IHC
- Brand: Saint Michael
- Catalogue No.: K106646P-20.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.
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