Anti-SPNS1 Polyclonal Antibody, 50.0ul

Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949).Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949).Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949).Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z, 7Z, 10Z, 13Z, 16Z, 19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949).Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine (PubMed:36161949).Essential player in lysosomal homeostasis (PubMed:36161949).May be involved in necrotic or autophagic cell death (PubMed:12815463).

• Size: 50.0ul
• Molecular Weight: 25/49/51/57kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Application: IHC
• Brand: Saint Michael
• Catalogue No.: K115011P-50.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.