Anti-TEAD2 Polyclonal Antibody, 50.0ul
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
- Size: 50.0ul
- Molecular Weight: 49kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze/thaw cycles.
- Application: WB
- Brand: Saint Michael
- Catalogue No.: K008687P-50.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.