Anti-USP18 Polyclonal Antibody, 100.0ul
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.
- Size: 100.0ul
- Molecular Weight: 41/43kDa
- Physical State: Liquid
- Storage: Store at -20℃. Avoid freeze/thaw cycles.
- Application: ELISA;WB
- Brand: Saint Michael
- Catalogue No.: K109681P-100.0ul
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.