Anti-VHL Polyclonal Antibody, 100.0ul

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

• Size: 100.0ul
• Molecular Weight: 19/20/24kDa
• Physical State: Liquid
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Application: IHC
• Brand: Saint Michael
• Catalogue No.: K114956P-100.0ul

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.