Cl-amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine TFA induces apoptosis in cancer cells. Cl-amidine TFA induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine TFA prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model[1-5].
- Size: 1mg
- Purity: ≥98%
- Molecular Formula: C 1 4 H 1 9 ClN 4 O 2 ·C 2 HF 3 O 2
- Molecular Weight: 424.8
- Physical State: Solid
- Storage: Powder:2-8℃, 2 years;Insolvent(Mother Liquid):-20℃, 6 months;-80℃, 1 year
- Brand: Saint Michael
- Catalogue No.: IC7440-1mg
For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.
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