Human Fcgr2b ELISA Kit, 48T

Receptors that recognize the Fc portion of IgG (Fccγ Rs) functions in the regulation of immune response and are divided into three classes designated Fccγ RI (CD64), Fccγ RII (CD32), and Fccγ RIII (CD16). Fccγ RI binds IgG with high affinity and functions during early immune responses, whereas Fccγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three closely related genes encodes human CD32 class by and designated Fccγ RII A, B, and C which share 94 - 99% amino acid identity in their extracellular domains. Fccγ RII B (CD32b) is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. As the only inhibitory member in human, Fccγ RII B has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. The coordinated functioning of activating and inhibitory receptors is necessary for successful and proper initiation, amplification, and termination of immune responses, and accordingly, the Fccγ RII B plays an important negativeregulating role through modulating the signals from activation receptors. Recent study has identified CD32b expression in a variety of B-cell malignacies, suggesting that it is a potential immunotherapeutic target for B-cell lymphoproliferative disorders.

• Size: 48T
• Storage: Store at 2-8℃
• Application: ELISA
• Brand: Saint Michael
• Catalogue No.: SEKH-0606-48T

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.