Rabbit ANP ELISA Kit, 48T

Atrial natriuretic peptide (ANP) is a powerful vasodilator, and a protein hormone secreted by heartmuscle cells. It is involved in the homeostatic control of body water, sodium, potassium and adiposetissue. It is released by atrial myocytes in response to high blood volume. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP has exactlythe opposite function of the aldosterone secreted by the zona glomerulosa in regard to its effect on sodiumin the kidney that is, aldosterone stimulates sodium retention and ANP generates sodium loss.Incardiac myocytes, ANP is made as a precursor form, i.e. prepro-ANP, a polypeptide of 151 aminoacids. After the signal peptide is removed in the endoplasmic reticulum, the 126-amino-acid pro-ANPis stored in the intracellular granules. When the cells are stimulated, pro-ANP is released and converted tothe 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serineprotease corin.ANP interacts with three receptors including guanylyl cyclase-A (NPR1), guanylylcyclase-B (NPR2), natriuretic peptide clearance receptor (NPR3). The binding of ANP to its receptorcauses the conversion of GTP to cGMP and raises intracellular cGMP. Receptor-agonist binding causes areduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure.Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the bodyis to counter increases in blood pressure and volume caused by the renin-angiotensin system. ANP andrelated peptides are used as biomarkers for cardiovascular diseases such as stroke, coronary arterydisease, myocardial infarction and heart failure.

• Size: 48T
• Storage: Store at 2-8℃
• Application: ELISA
• Brand: Saint Michael
• Catalogue No.: SEKRT-0213-48T

For laboratory research use only. Not for human or animal consumption, diagnostic or therapeutic use.